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When a compound like DES is introduced into the body and doesn't bind with the blood proteins, it can be as much as 100 times more potent than natural estradiol in the fetus. In another example, bisphenol A, by not binding to SHBG, has higher activity levels in the fetus than when tested in the lab."

Fetal exposure to hormones can program the way a gene functions for the rest of a person's life. Some genes are supposed to be turned on early in life, some later. If a fetus or developing child is exposed to a potent hormone disrupter during a specific window of vulnerability, the molecular path their cells take may be altered, possibly permanently. A girl may show signs of puberty at age five instead of during early teen years. A boy's testicles may not descend. Intelligence may be affected. Sustained attention or response to stress may be altered. Individuals respond differently to these different signals.



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